دکتر محسن کشاورز

 

Curriculum Vitae

 

The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran

Mohsenkeshavarz1990@gmail.com , Keshavarz.m@bpums.ac.ir

 

 

EMPLOYMENT EXPERIENCE

         Assistant Professor, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.

EDUCATION

          Ph.D. in Virology, Department of virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran (2015 to 2019).

Thesis Title: Evaluation of the antitumor activity of Bone Marrow Mesenchymal Stem Cells- Based Carrier for oncolytic Newcastle disease virus in human papillomavirus-associated tumor mice model.

Supervisor: Dr. Amir Ghaemi

 

          M.Sc. in Virology, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran (2012-2015).

Thesis Title: The pattern of expression of cytokine and chemokine involved in influenza virus infection in BALB /c mice following immunization with influenza virus-like particles (VLPs). Supervisor: Dr. Farhad Rezaei

 

          B.Sc. in Medical Lab. Sciences, Bushehr University of medical science, Bushehr, Iran.

 

RESEARCH EXPERIENCE

 

         Head of Virology Lab at the Persian Gulf Tropical Medicine Research Center (BPUMS) (2020-2023).

           Collaboration with the Pasteur Institute of Iran, Influenza and other respiratory viruses center (2017-2019).

          Doctorate Student, Department of virology, Iran university of Medical Sciences (2015-2019).

          Graduate student, National Influenza Center, Department of Virology, Tehran University of Medical Sciences (2012-2015).

 

RESEARCH INTERESTS

 

          Oncolytic Viruses, Antiviral compounds, Vaccine, Respiratory Viruses

 

PUBLICATIONS

 

      Maryam Ghotbi, Mohsen Keshavarz, Najmeh Parhizgari, Talat Mokhtari-Azad, Nazanin Zahra Shafiei-Jandaghi, Farhad Rezaei. BK Virus Infection in Kidney Transplant Recipients: Genotypic Variations and Clinical Outcomes in Tehran, Iran (2018–2019). Viral Immunology. https://doi.org/10.1089/vim.2024.0077

      Reza Nedaeinia, Hassan Dianat-Moghadam, Maedeh Movahednasab, Zahra Khosroabadi, Mohsen Keshavarz, Zohreh Amoozgar, Rasoul Salehi. Therapeutic and prognostic values of ferroptosis signature in glioblastoma. International Immunopharmacology. https://doi.org/10.1016/j.intimp.2025.114597

      Mohsen Keshavarz, Mohsen Ghorbani, Forough Shamsizadeh, Haideh Namdari, Vahid Salimi, Farhad Rezaei. Effects and Mechanisms of Silibinin on Influenza A/H1N1 Pathogenesis in a Mouse Model. Journal of Tropical Medicine.  https://doi.org/10.1155/jotm/6618423

      Keshavarz, M*., Dianat-Moghadam, H., Ghorbanhosseini, S.S., Sarshari, B. Oncolytic virotherapy improves immunotherapies targeting cancer stemness in glioblastoma. Biochimica et Biophysica Acta (BBA). https://doi.org/10.1016/j.bbagen.2024.130662.

 

      Neda Baghban, Safieh Momeni, Emad Behboudi, Hassan Dianat-Moghadam, Amirhossein Darabi, Hadiseh Shokouhi Targhi & Mohsen Keshavarz*. Green synthesis of MnO2 NPs using Arabic gum: assessing its potential antiviral activity against influenza A/H1N1. Virology Journal. https://doi.org/10.1186/s12985-024-02315-z

      Soheila Binabaji, Mohammad Rahimi, Hamid Rajabi, Mohsen Keshavarz, Rahimeh Rahimi, Azam Ahmadi & Daniel Gahreman. Effects of physical training on coagulation parameters, interleukin- 6, and angiotensin-converting enzyme-2 in COVID-19 survivors. Scientific Reports. https://doi.org/10.1038/s41598-024-67522-8

      Nahid Darabi, Mohsen Keshavarz, Iraj Nabipour, Majid Assadi. The sodium iodide symporter (NIS) as theranostic gene: potential role in pre-clinical therapy of extra-thyroidal malignancies. Clinical and Translational Imaging. 2023. https://doi.org/10.1007/s40336-023-00540-0.

      Dianat-Moghadam H, Sharifi M, Salehi R, Keshavarz M, Shahgolzari M, Amoozgar Z. Engaging stemness improves cancer immunotherapy. Cancer Letters. 2023 Nov 14:216007. https://doi.org/10.1016/j.canlet.2022.216007.

      Seyed Mohammad Miri., Behzad Pourhossein, Seyed Younes Hosseini, Mohsen Keshavarz, Shohreh Shahmahmoodi, Mohammad Reza Zolfaghari, Seyed Reza Mohebbi, Ali Gorji, Amir Ghaemi .Enhanced synergistic antitumor effect of a DNA vaccine with anticancer cytokine, MDA 7/IL-24, and immune checkpoint blockade. (2022). https://doi.org/10.1186/s12985-022 01842- x.

  Keshavarz, M., Mohammad Miri, Behboudi, E., Arjeini, Y., Dianat-Moghadam, H., Ghaemi, A. Oncolytic virus delivery modulated immune responses toward cancer therapy: Challenges and perspectives. (2022). DOI: 10.1016/j.intimp.2022.108882.

  Mahmudpour, M., Vahdat, K., Keshavarz, M., Nabipour, I. The COVID-19-diabetes mellitus molecular tetrahedron. (2022). DOI: 10.1007/s11033-021-07109-y.

  Ahmadi Vasmehjani, A., Rezaei, F., Farahmand, M., Mokhtari-Azad, T., Yaghoobi-Ershadi, M. R., Keshavarz, M., Baseri, H.R., Zaim, M., Iranpour, M., Turki, H., EsmaeilpourBandboni, M. Epidemiological evidence of mosquito-borne viruses among persons and vectors in Iran: A study from North to South. (2022). DOI: 10.1016/j.virs.2022.01.005.

   Keshavarz M, Janati-Namin N, Arjeini Y, Mokhtari-Azad T, Rezaei F. Prevalence and genotypic characterization of human parvovirus B19 in hemophilia patients. Iranian Journal of Microbiology. 2022 Aug 14;14(4):568-73.

  Shahgolzari, M., Yavari, A., Arjeini, Y., Miri, S.M., Darabi, A., Mozaffari Nejad, A.S., Keshavarz, M*. Immunopathology and Immunopathogenesis of COVID-19, what we know and what we should learn. (2021). DOI: 10.1016/j.genrep.2021.101417.

  Koushki, K., Salemi, M., Miri, S.M., Arjeini, Y., Keshavarz, M*, Ghaemi, A. Role of myeloidderived suppressor cells in viral respiratory infections; Hints for discovering therapeutic targets for COVID-19. (2021). DOI: 10.1016/j.biopha.2021.112346.

  Dianat-Moghadam, H., Khalili, M., Keshavarz, M., Azizi, M., Hamishehkar, H., Rahbarghazi, R., Nouri, M. Modulation of LXR signaling altered the dynamic activity of human colon adenocarcinoma cancer stem cells in vitro. (2021). DOI: 10.1186/s12935-021-01803-4.

 

  Mahmudpour, M., Nabipour, I., Keshavarz, M., Farrokhnia, M. Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors. (2021). DOI: 10.3389/fchem.2021.722633.

  Keshavarz, M., Sabbaghi, A., Koushki, K., Miri, S.M., Sarshari, B., Vahdat, K., Ghaemi, A. Epigenetic reprogramming mechanisms of immunity during influenza A virus infection. (2021) . DOI: 10.1016/j.micinf.2021.104831.

  Koushki, K., Shahbaz, S.K., Keshavarz, M., Bezsonov, E.E., Sathyapalan, T., Sahebkar, A. Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders. (2021) . DOI: 10.3390/biom11091289.

  Keshavarz, M*., Shamsizadeh, F., Tavakoli, A., Baghban, N., Khoradmehr, A., Kameli, A., Rasekh, P., Daneshi, A., Nabipour, I., Vahdat, K., Farrokhnia, M., Tamadon, A. Chemical compositions and experimental and computational modeling activity of sea cucumber Holothuria parva ethanolic extract against herpes simplex virus type 1. (2021). DOI: 10.1016/j.biopha.2021.111936.

  Ahmadikia, K., Mahmoudi, S., Hassanali, F., Keshavarz, M., Mirhendi, H., Malekzadeh, E. A Review on the diagnostic approaches of COVID-19 infection; Features and limitations. (2021). DOI: 10.22122/jims.v39i611.13023.

  Mozhgani, S.-H., Keshavarz, M., Mousavi, N., Namdari, H., Salimi, V., Mokhtari-Azad, T., Zarei- Ghobadi, M., Nadji, S.A., Ghavami, N., Rezaei, F. Frequent detection of enterovirus D68 and rhinovirus type C in children with acute respiratory infections. (2021). DOI: 10.1007/s10096-020- 04051-y.

  Omrani, M., Keshavarz, M., Nejad Ebrahimi, S., Mehrabi, M., McGaw, L.J., Ali Abdalla, M., Mehrbod, P. Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines. (2021). DOI: 10.3389/fphar.2020.586993.

  Keshavarz, M*., Tavakoli, A., Zanganeh, S., Mousavi, M.J., Vahdat, K., Mahmudpour, M., Nabipour, I., Darabi, A., Keshmiri, S. Clinical characteristics of outpatients and inpatients with COVID-19 in Bushehr: A report from the south of Iran. (2021). DOI: 10.2217/fvl20200231.

  Sabbaghi, A., Miri, S.M., Keshavarz, M., Mahooti, M., Zebardast, A., Ghaemi, A. Role of γδ T cells in controlling viral infections with a focus on influenza virus: implications for designing novel therapeutic approaches. (2020). DOI: 10.1186/s12985-020-01449-0.

  Mozaffari Nejad, A.S., Fotouhi, F., Mehrbod, P., Keshavarz, M., Alikhani, M.Y., Ghaemi, A. Oncolytic effects of Hitchner B1 strain of newcastle disease virus against cervical cancer cell proliferation is mediated by the increased expression of cytochrome C, autophagy and apoptotic pathways. (2020) . DOI: 10.1016/j.micpath.2020.104438.

  Mahmudpour, M., Roozbeh, J., Keshavarz, M., Farrokhi, S., Nabipour, I. COVID-19 cytokine storm: The anger of inflammation. (2020). DOI: 10.1016/j.cyto.2020.155151.

  Assadi, M., Gholamrezanezhad, A., Jokar, N., Keshavarz, M., Picchio, M., Seregni, E., Bombardieri, E., Chiti, A. Key elements of preparedness for pandemic coronavirus disease 2019 (COVID-19) in nuclear medicine units. (2020). DOI: 10.1007/s00259-020-04780-4.

  Keshavarz, M., Ebrahimzadeh, M.S., Miri, S.M., Dianat-Moghadam, H., Ghorbanhosseini, S.S., Mohebbi, S.R., Keyvani, H., Ghaemi, A. Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment. (2020) . DOI: 10.1186/s12985-020-01326-w.

  Dianat-Moghadam, H., Heidarifard, M., Mahari, A., Shahgolzari, M., Keshavarz, M., Nouri, M., Amoozgar, Z. TRAIL in oncology: From recombinant TRAIL to nano- and self-targeted TRAIL- based therapies. (2020). DOI: 10.1016/j.phrs.2020.104716.

  Keshavarz, M., Sabbaghi, A., Miri, S.M., Rezaeyan, A., Arjeini, Y., Ghaemi, A. Virotheranostics, a double-barreled viral gun pointed toward cancer; Ready to shoot? (2020) . DOI: 10.1186/s12935- 020-01219-6.

  Mostafaei, S., Keshavarz, M., Sadri Nahand, J., Farhadi Hassankiadeh, R., Moradinazar, M., Nouri, M., Babaei, F., Ahadi, M., Payandeh, M., Salari Esker, A., Hajighadimi, S., Mirzaei, H., Moghoofei,

M. Viral infections and risk of thyroid cancer: A systematic review and empirical bayesian meta- analysis. (2020) . DOI: 10.1016/j.prp.2020.152855.

  Keshavarz, M., Solaymani-Mohammadi, F., Namdari, H., Arjeini, Y., Mousavi, M.J., Rezaei, F. Metabolic host response and therapeutic approaches to influenza infection. (2020). DOI: 10.1186/s11658-020-00211-2.

  Karbalaie Niya, M.H., Keshavarz, M., Safarnezhad Tameshkel, F., Taherizadeh, M., Esghaei, M., Panahi, M., Keyvani, H. Investigation of JC polyomavirus (JCV) genome in colorectal cancer patients from Iran. (2020).

  Keshavarz, M., Nejad, A.S.M., Esghaei, M., Bokharaei-Salim, F., Dianat-Moghadam, H., Keyvani, H., Ghaemi, A. Oncolytic Newcastle disease virus reduces growth of cervical cancer cell by inducing apoptosis. (2020) . DOI: 10.1016/j.sjbs.2019.04.015.

  Sabbaghi, A., Miri, S.M., Keshavarz, M., Zargar, M., Ghaemi, A. Inactivation methods for whole influenza vaccine production. (2019). DOI: 10.1002/rmv.2074.

  Moghoofei, M., Keshavarz, M., Ghorbani, S., Babaei, F., Nahand, J.S., Tavakoli, A., Mortazavi, H.S., Marjani, A., Mostafaei, S., Monavari, S.H. Association between human papillomavirus infection and prostate cancer: A global systematic review and metaanalysis. (2019) . DOI: 10.1111/ajco.13124.

  Keshavarz, M., Namdari, H., Arjeini, Y., Mirzaei, H., Salimi, V., Sadeghi, A., Mokhtari-Azad, T., Rezaei, F. Induction of protective immune response to intranasal administration of influenza virus-like particles in a mouse model. (2019) . DOI: 10.1002/jcp.28339.

  Keshavarz, M., Solaymani-Mohammadi, F., Miri, S.M., Ghaemi, A. Oncolytic paramyxoviruses- induced autophagy; A prudent weapon for cancer therapy. (2019) . DOI: 10.1186/s12929-019- 0542-9.

  Keshavarz, M., Namdari, H., Farahmand, M., Mehrbod, P., Mokhtari-Azad, T., Rezaei, F. Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population. (2019). DOI: 10.1186/s12985019-1187-8.

  Keshavarz, M., Mirzaei, H., Salemi, M., Momeni, F., Mousavi, M.J., Sadeghalvad, M., Arjeini, Y., Solaymani-Mohammadi, F., Sadri Nahand, J., Namdari, H., Mokhtari-Azad, T., Rezaei, F. Influenza vaccine: Where are we and where do we go? (2019). DOI: 10.1002/rmv.2014.

 

Niya, M.H.K., Tameshkel, F.S., Alemrajabi, M., Taherizadeh, M., Keshavarz, M., Rezaee, M., Keyvani, H. Molecular survey on merkel cell polyomavirus in patients with colorectal cancer. (2018). DOI: 10.13181/mji.v27i4.2759.

  Keshavarz, M., Niya, M.H.K., Tameshkel, F.S., Nejad, A.S.M., Monavari, S.H., Keyvani, H. A survey on human T-cell lymphotropic virus type 1 (HTLV-1) and xenotropic murine leukemia virus- related virus (XMRV) coinfection in Tehran, Iran. (2018). DOI: 10.4103/JPBS.JPBS_25_18.

  Keshavarz, M., Dianat-Moghadam, H., Sofiani, V.H., Karimzadeh, M., Zargar, M., Moghoofei, M., Biglari, H., Ghorbani, S., Nahand, J.S., Mirzaei, H. MiRNA-based strategy for modulation of influenza A virus infection. (2018). DOI: 10.2217/epi-2017-0170.

  Keshavarz, M., Tavakoli, A., Nejad, A.S.M., Mokhtari-Azad, T., Rezaei, F. A review of influenza vaccination among different population groups in Iran. (2018). DOI: 10.7860/JCDR/2018/35486.11647.

  Esghaei, M., Moghoofei, M., Keshavarz, M., Keyvani, H., Bokharaei-Salim, F., Farahmand, M., Monavari, S.H. Trends in surveillance data of influenza virus in Tehran before decreasing dispatch of Iranian Hajj pilgrims to Mecca. (2018). DOI: 10.14196/mjiri.32.41.

  Tavakoli, A., Niya, M.H.K., Ghaffari, H., Keshavarz, M., Keyvani, H. Role of T lymphocytes and natural killer cells in athogenesis of chronic viral hepatitis. (2017).

  Monavari, S.H.R., Hadifar, S., Mostafaei, S., Miri, A., Keshavarz, M., Babaei, F., Moghoofei, M.

Epidemiology of rotavirus in the Iranian children: A systematic review and meta-Analysis .(2017)

. DOI: 10.4103/0974-777X.205173.

Tavakoli, A., Karbalaie Niya, M.H., Keshavarz, M., Ghaffari, H., Asoodeh, A., Monavari, S.H., Keyvani, H. Current diagnostic methods for HIV. (2017). DOI: 10.2217/fvl-2016-0096

  Nadmdari, H., Keshavarz, M., Mokhtari-Azad, T., Rezaei, F. Evaluation of antibody and cytokines responses in intranasally and intramuscularly administrated BALB/C mice with influenza virus- like particle. (2017).

   Darabi A, Sarshari B, Vahdat K, Mousavi A, Keshavarz M*. 2023. Frequent detection and genotyping of human rhinovirus in patients with acute respiratory infections; A study from south of Iran. DOI: https://doi.org/10.18502/ijm.v15i3.12908

  Keshavarz M, Ghasemi S, Arjeini Y, Namdari H, Maleki H, Mousavi N, Mokhtari‐Azad T, Rezaei F. Frequency evaluation and molecular characterization of HHV‐6 and HHV‐7 among children under 5 years with fever and skin rash. DOI: https://doi.org/10.1002/jmv.28608

  Sarshari B, Zareh-Khoshchehreh R, Keshavarz M, Manshadi SA, SeyedAlinaghi S, Aghdaei HA, Mohebbi SR. The possible role of viral infections in pancreatitis: A narrative review: Viruses and Pancreatitis. https://doi.org/10.22037/ghfbb.v16i2.2582

BOOKS

          Clinical Virology. Feb, 2017. Baresh Danesh. (110 pages, in Persian)

 

 

RESEARCH GRANT SUPPORT in the role of PRINCIPLE INVESTIGATOR

 

 

 

          Project Grant (1423): Deputy ministry of research, Bushehr University of Medical Sciences. Title of project: Investigation on the possible role of human herpes virus type 4 (EBV) in thyroid cancer.

         Project Grant (1572): Deputy ministry of research, Bushehr University of Medical Sciences. Title of project: Evaluation of clinical, laboratory and imaging findings in coronavirus patients referred to Bushehr hospital.

          Project Grant (1860): Deputy ministry of research, Bushehr University of Medical Sciences. Title of project: phylogenetic analysis of Rhinoviruses

          Project Grant (1431): Deputy ministry of research, Bushehr University of Medical Sciences. Title of project: Antiviral and anti-inflammatory effect of Sea Cucumbers extract (Holothuria sp.) on herpes simplex virus.

          Project Grant (2203 ): Deputy ministry of research, Bushehr University of Medical Sciences. Title of project: Investigating the antiviral activity of MNO2 nanoparticles using the green synthesis method.

 

AWARDS

 

          2021-2022 Top Scholar Award in Bushehr University of Medical Sciences, Bushehr, Iran.

          2020-2021 Top Scholar Award in the Persian Gulf Biomedical Sciences Research Institute, Bushehr, Iran.

 

 

 

TECHNICAL SKILLS

 

          Cancer immunotherapy testing and modelling

          T cell biology assessments

          Flow cytometry

          Basic molecular biology (DNA/RNA extraction, RFLP, PCR, RT-PCR, Real- Time PCR and DNA Sequencing, Western blot, cloning).

          Mammalian cell culture (Subculture & Infection).

          Gold-standard virology techniques (Virus cultivation, Virus titration).

          Molecular epidemiology and phylogenetic tree analysis

         Molecular Docking.

Working with laboratory animals.